Review Assignment Example | Topics and Well Written Essays - 1500 words

Review - Assignment Example Gandhi stated that, the actual meaning of civilization is ‘good conduct’, which can only come through the existence of villages. These were the people who outwardly argued with their views on the thought urban renovation. According to Jane Jacobs, the survival is impossible from World Bank. Considering the levels of urbanization and GDP per capita, they both are directly linked with each other. Due to it, the argument about the development of countryside areas on their expenses itself, has been in light from ages. The development, social justice and status discrimination (cities dominating the countryside) crisis also relate the argument. Cheap food coming out of the agriculture and their import export has also been the factor of criticism by 2008, where most of the countries imposed ban on the exports by increasing the subsidy on crops. That is the reason which backs the idea of under-funding of agriculture. Overviewing the entire scenario, Urban Bias Thesis (UBT) came into being, to resolve the crisis against Gandhi’s claim, food crisis and price issues associating the rural development. Lipton was the man who analyzed this thesis into details. The claims of Lipton involved the price issue on rural commodities which were decrease, and those of the urban bias increased outside Latin America. In 2000, the extreme increase of urban bias in China has been seen. The main discussion point of Lipton was that, reduce in urban bias haven’t been fulfilled, considering the terms of economic liberation and structural adjustments. This debate took peak under the light of four circumstances; matters of measure & definition, urban poverty, causes & consequences of urban growth and the value of rural & and urban in complex livelihood strategies & interdependencies. The main understanding which should be look up to here is the mobility benefits

A proposal for company market expansion scheduled for completion by Research Paper

A proposal for company market expansion scheduled for completion by 2023 - Research Paper Example It is an American company with its headquarters in Stamford. The company offers both hotel and leisure services. Some of the properties owned by the company include spas, resorts, vacation properties and hotels. More over, the corporation owns and operates franchises (Great Britain & British Oversees Trade Board, 2004). Background information of the Starwood Hotel and Resorts Starwood Hotel is an effusive incorporated owner, worker and franchisor of hotels. The company was initially established by the real estate investment firm called Starwood Capital. The intention of the formation was to take advantage of the tax break. Frits Van Paasschen is the current CEO. The Starwood Hotel and Resort Company have a chain of brands spread across the globe. They include Westin, Sheraton, W Hotels, St. Regis, Le Meridien, Aloft and Element. The company has over 1,134 properties in over 100 nations (Gibler, Gibler, & Anderson, 2010). Moreover, it has a global employee capacity of 154,000. Starwoo d enjoys massive marketing and customer retention through its program â€Å"Starwood Preferred Guest†. The program allows members to redeem points for services offered such as room stay and flights. It is imperative to note that the luxury hotels and resorts incorporated in the Starwood Company offer unique and authentic experiences that evoke lasting memories. Moreover, for any global voyager, the collection offers an entrance to the world’s most exhilarating and attractive destinations (Gibler, Gibler, & Anderson, 2010). The luxury hotels and resorts have exceptional and cherished appearance of the location, native charms and treasures. Starwood hotels and Resort Company embrace cultural diversity. This is the sole reason as to why it has extensively established across the globe. The company sustains an associate and clientele base as diverse as the globe’s population. The diverse brands spread all over the world give Starwood a distinctive cultural identity w hich accommodates diversity. This trend of operation embraced by the company’s management as created distinctive appeal in the global market. It is factual that, expanding the operations of the company to the United Arab Emirates may not be faced by cultural based complication (Hudson, 2010). This practice has enhanced the company’s objective of inclusion of people of all races with diverse political, economic and social backgrounds. Indeed, the culture of diversity in Starwood Hotels & Resorts, Inc. is further enhanced by unique blending and mining of the associates’ talents from across the globe. The top management commitment to ensure cultural diversity is enhanced in a shared responsibility with the chain of associates spread globally. According to the company’s interests, the Starwood intends to reduce the socio-cultural gap among the employees drawn from across the globe. This kind of integration satisfies the company’s values of internationa l cooperation and amalgamation (Hudson, 2010). This practice remains the key motivation to the success of the numerous centers of the company located all over the globe. Literature review The new market in the United Arab Emirates The extent and enormity of how much the UAE has developed in nature, predominantly in the last decade, is exemplary, even beyond the international standards. This tremendous expansion in political, social and economic areas has put the UAE in the

Family in Later Life Essay Example | Topics and Well Written Essays - 500 words

Family in Later Life - Essay Example In the recent past there has been an increase in the number of singles in the US. The word single implies a person who is unmarried, but it is more widely used to refer to all those people who are either divorced or are staying alone because their spouses have expired. For research purposes the term single is taken in its broader meaning, to include any person who lives alone, whether married or otherwise. For understanding the trends in being single in later life one needs to examine the experiences of the elderly as to how they experience life when living alone. â€Å"The trends that underlie increased rates of staying single among younger age groups reflect the interplay of social change and demographic shifts.† (Ingrid Arnet Connidis, 2009, P.96). When people are single at an elderly age then they remain quite isolated from the society and are less social unlike those elderly who have a family. They are not attracted towards their relatives but are closer to friends who ar e also singles. However, in such a case there is a difference in the concept of both the genders. While the single males prefer friends more as companions older females prefer relatives as companions. There is an increasing trend in criminal cases against the elderly who are single such as telemarketing scams.

Catholic Teachings Essay Example | Topics and Well Written Essays - 1750 words

Catholic Teachings - Essay Example Catholic teaching teaches its followers that they should not be better off than the followers of other religions. However, the world is still filled with many poor and underprivileged people while very rich religious people and institutions continue to bask in their wealth. Catholics believe that they should work towards eradicating poverty and assist others in improving their living standards. Catholics basically follow the First Article of the Universal Declaration of Human Rights which says: freedom from fear and want has been proclaimed as the highest aspiration of the common people. the peoples of the United Nations havedetermined to promote social progress and better standards of life in larger freedom. "For I was hungry and you gave me something to eat, I was thirsty and you gave me something to drink, I was a stranger and you invited me in, I needed clothes and you clothed me, I was sick and you looked after me, I was in prison and you came to visit me." Matthew 25:35-36 Every individual is both sacred and social. A person appreciates his or her dignity and rights in relationship with others in the community. The community must allow all individuals to grow and achieve fulfilment. The organization of society - in economics and politics, in law and policy - directly influences human dignity and the ability for individuals to develop in community. The compulsion to "love our neighbour" not only has an individual aspect, but it also involves a broader social obligation. Each person is responsible in contributing to the good of the whole society. This behaviour spread throughout all communities in every nation will lead to moral world development and encourages individuals to strive to attain better world economic development. Society is judged morally by the way it treats its poorest citizens as the plight of the poor demands a moral claim from the conscience of the community. Powerlessness and deprivation of the poor hurts the whole community.A community can be strengthened if its members give greater attention to the needy and those at society's fringes. The economy must serve people, not the other way around. Workers have a right to productive work, to fair wages, and to safe working conditions. They also have a right to

Fashion for a cause Essay Example for Free

Fashion for a cause Essay Having a ribbon on your outfit to support a cause is a thing of past. Today a brand needs to be more deeply involved with different social causes as well as provide us with fashionable clothes. But what is the primary motivation for a buyer in this scenario? Does he buy such products because he wants to support the social cause behind it or because of the product itself and the brand name it carries? Is it just a onetime buy? Is the consumer completely aware about the social concern the product is working for? Are the Indian customers ready to adopt such brands? Objectives 1. To understand if there is a direct relationship between the social concern factor and the brand equity of the product. 2. To know the primary motivation of the buyer of such brands. 3. To check the brand loyalty of these consumers for such brands. 4. To check if the consumers are aware of the social concern around which the product is being promoted. 5. To check if the consumers in India are ready to adopt such social brands. 2 CHAPTER 2 3 Review of Literature (Fernandez, 2013) ‘It is not how much we give, but how much love we put into giving,’ wise words by Mother Teresa. In today’s world that is fuelled by money, it is endearing to find people who try to fuel the world with love and so, it is in this nature that companies have started to verge toward campaigns themed with more ‘selfless giving‘. In the past few years there have been a trend towards various noble causes: charity events, concerts, and other philanthropic endeavours brought about by various companies in a number of industries. There are also a wide a number of advocacies that include: AIDS, HIV, cancer, global warming, gay rights, and many others, in need of charitable donations. And while the whole idea of fashion-brands-going-the-extra-mile-for-a-better-cause may give us the warm feeling and a restored faith in humanity, there is still that quiet looming reminder that in the world of business, nothing comes free. (Times of India, 2013) Fashion may be used to promote a cause, for example, to promote healthy behaviour, to raise money for a cancer cure, to raise money for local charities, for example a Juvenile Protective Association, (Martin, 2013) or to raise donations for a childrens hospitals. (Sultan, 2011) â€Å"Most people do not take the time to donate to the charities yet a small donation can make a very big difference in another persons life. The most important aspect of donating to charity is the fact that you will be helping out a needy person get basic human necessities improving a life in the process. † In today’s busy life not many people take out time to make donations and do charity work but everyone has time to buy new clothes and if buying these clothes can help someone in need wouldn’t that be worth it? (Singh, 2013) â€Å"The global appeal and charitable nature of stores like Being Human not only gives a unique shopping experience to the customers, but also gives them satisfaction of doing good. † The idea of following a film star always appeals to the masses. (Khan, 2013) â€Å"All fashion labels are about looking good, Being Human is also about doing good. † (Beig, 2013) â€Å"Wearing Being Human means you ‘look good, do good’ because you help people by the simple act of slipping on your clothes every day. † (Mandhana, 2013) â€Å"The ‘Being Human’ line is designed to offer comfort, quality and style while supporting an endeavour of good cause. † (Chase, 2009) In a study of how a clothing brands affiliation with a social cause would affect buyers spending habits the research team conducted a survey of Generation Y college students to find out how their support of an existing line of apparel, 7 For All Mankind, might change should the brand begin campaigning with, say, Breast Cancer Awareness. The study reported that both college men and women would hold such brands to a higher esteem in general, and 89% would likely switch from Brand A to Brand B if Brand B was associated with a socially/environmentally focused cause (assuming price and quality are held constant). Additionally, 72. 4% stated they had intentionally purchased a brand name product due to the fact that the brand was affiliated with a cause they agreed with. 4 (Markson, 2012) Purpose is being integrated into marketing efforts in more concerted ways and with favourable consumer response. According to Markson, the marketing world is coming to an understanding that purpose must carry as much weight in crafting an effective ad campaign as the traditional Four Ps of Marketing: Price, Placement, Product and Promotion. In the United States, after quality and price, social purpose (at 47 percent) ranks higher as a purchase motivator than brand loyalty (27 percent) and design and innovation (26 percent). In addition, if a brand of similar quality supports a good cause, 75 percent of consumers claim they would buy it and 76 percent claim they would recommend and share positive experiences about such a brand. Sixty-two percent of U. S. consumers say they would also switch brands if a brand of similar quality supported a good cause. Finally, U. S. consumers willingness to actually promote a brand that supports a good cause jumped 19 percent from 2008 (47 percent) to 2010 (66 percent). (Barkley Cause Survey, 2010) A full 88 percent of American men say it is important for a brand to support a cause. Such a finding points to a new masculine ideal taking hold, an evolution beyond the bad-boy tough guy ideal. American men are comfortable with having a good heart. Maybe they dont want to wear it on their sleeve. But they do want to contribute through their purchases, and in fact a majority demands it, 55 percent of men said they would switch brands from a company that did not support a cause to one that did. (Storm, 2013) Fashion is fun, but sometimes it’s more than that. Certain brands answer to a higher calling than simply making shoppers look fabulous and consumers seem willing to pay extra for it. According to Nielsen’s Global Corporate Citizenship Survey, 46 percent of consumers are willing to pay more for products and services from companies that give back to society. (Nielsen, 2012) New findings from a Nielsen survey of more than 28,000 online respondents from 56 countries around the world provide fresh insights to help businesses better understand the right audience for cause marketers, which programs resonate most strongly with this audience, and what marketing methods may be most effective in reaching these consumers. In the study, respondents were asked if they prefer to buy products and services from companies that implement programs that give back to society. Anticipating a positive response bias, respondents were also asked whether they would be willing to pay extra for those services. For the purposes of this study, Nielsen defines the â€Å"socially conscious consumer† as those who say they would be willing to pay the extra. Two thirds (66%) of consumers around the world say they prefer to buy products and services from companies that have implemented programs to give back to society. That preference extends to other matters, too: they prefer to work for these companies (62%), and invest in these companies (59%). A smaller share, but still nearly half (46%) say they are willing to pay extra for products and services from these companies. These are the â€Å"socially conscious consumers,† as defined by and focused upon in this report. Sixty three percent of global, socially-conscious consumers are under age 40, they consult social media when making purchase decisions and are most concerned about environmental, educational and hunger causes, according to a new study from Nielsen, a leading global provider of information and insights into what consumers watch and buy. 5 6 Few of the brands I came across during my research: 2. 1 Sseko Designs Mission and Impact on Sseko Designs official webpage: Sseko Designs uses fashion to provide employment and scholarship opportunities to women pursuing their dreams and overcoming poverty. To date, theyve enabled 33 to continue on to University. They provide employment (along with access to a comprehensive social impact program) to their team of 45 women in Uganda. And they do it all through a financially selfsustaining model. Issue 1: Female students, due to a lack of economic opportunity, are not able to continue on to university and pursue leadership positions in society. Solution 1: Sseko Designs provides employment during the 9 month gap between high school and university where high potential young women are able to earn and save enough money to pay for college tuition. 50% of their salary each month goes into a savings account that is not accessible until tuition is due. This ensures that their income goes towards education. This also protects the women in the program from the social pressure they often feel from their families to give away the money they are earning which can perpetuate the cycle of poverty. At the end of each term, Sseko Designs grants university scholarships that match up to 100% of the savings each woman has made during her 9 month session with Sseko. Issue 2: In a patriarchal and male dominated society, women are not afforded the same employment and economic opportunities as their male counterparts. Although 66% of the worlds labour is done by women, they own less than 1% of the worlds assets. As long as women are not afforded educational and professional equality, extreme poverty will continue to exist. Solution 2: For every dollar a women in a developing economy earn, she will reinvest 90% of it into her family. Empower a woman and you empower an entire community. In addition to providing employment to women working their way towards university, Sseko partners with women from all walks of life. Sseko employs university graduates who comprise the upper level management team. These are women that use their education, experience and voice to help shape their company. Sseko also works to provide employment for women who have aged out of the education system and have no other form of income generation. They partner with a local non-profit in Uganda that works with young women who have recently come out of the commercial sex industry. Providing stable, dignifying and fair wage employment is a key component to keeping women from entering back into prostitution. They believe that every woman has the capacity to end the cycle of poverty and that it can be done in a way that is fair, dignifying, honouring and life-giving. Issue 3: Although charities and non-profits play a vital and necessary role in all societies, sometimes charity and aid can play a negative role by enabling dependencies and damaging the local economies. Like any of us, our African friends need and desire opportunity, dignity, job creation and empowerment. Solution 3: Instead of treating the symptoms, they aim to address the deeper, underlying issues of extreme poverty. Although Sseko Designs has been built for the purpose of impacting a 7 specific social sector, they have chosen very intentionally to use a sustainable, self-sufficient business model to do this. Their hope is to help create industry and fair-trade with the belief that a large component of economic development lies in the business sector. They believe in the power of responsible consumerism. Instead of competing for limited donor dollars, they hope consumers will think about the story behind their stuff. If they considered the impact that each product they consume has on the lives of those who produced that product and chose to see consumerism as a force and opportunity for positive social change, they believe the world would be filled with beautiful products with even more beautiful stories. 2. 2 World Clothes Line Everyone loves the smell of a clean t-shirt. Or the feeling of a new sweatshirt, soft. Or the look of a brand new outfit, confident and ready to conquer the day. Yet every day, millions of people around the world do not have a clean change of clothes. No options. No choice. World Clothes Line is dedicated to helping them. World Clothes Line will match every item sold with a new item for someone in need. Therefore, when customers purchase merchandise for themselves, they also provide clothing for others. In January 2010, World Clothes Line was born. 2. 2. 1 Their Vision As given in their name, their vision is to clothe the world. At World Clothes Line, they give clothes to people who need them. Through the generosity of their customers and dedication of their team, they hope to spread their message and continually help others. Their shoot for the stars goal is to create an active clothing collection for every country of the world. 2. 2. 2 Their Clothes Their styles are basic: t-shirts, sweatshirts, pants. Their main concerns are functionality, protection, and comfort. The designs are unique. They find that most people are inspired by the world. Every World Clothes Line collection is designed specifically to reflect its countrys people and culture. World Clothes Line is a socially conscious brand. All items are manufactured sweatshop-free at fair wages with environmentally-friendly practices. 8 2. 2. 3 Why Clothes? Clothing is one of our most basic needs. It ranks among air, food, water, and shelter. Clothing provides protection from the elements, reducing the effects of sun exposure, wind rash, and frostbite. It also provides defence against diseases, many of which are spread through mosquitoes and other insect bites. Proper clothing contributes to cleanliness, comfort, ease of movement and overall health. The simple act of changing and washing clothes can prevent infection, chafing, skin disorders and the spreading of viruses. However, in cases of extreme poverty, clothing is often one of the first needs to be ignored. Statistically, more than one billion people in the world live on less than one dollar a day. Almost 2. 7 billion people (thats 40% of our population) survive on less than two dollars per day. In such circumstances, daily necessities like food and water take top priority. Clothing, which can be reworn, therefore is reworn. Day after day. After day At World Clothes Line, they make clothes their number one priority. 2. 3 No One Without N. O. W: One At A Time No One Without water is their non-stop mission. Every product in a purchase provides clean water to one person for 25 years through a concrete Bio-sand filtration system and their partnership with Thirst Relief International. Studies have proven that these filters effectively remove more than 90% of bacteria and 100% of the parasites found in untreated water. Nearly one billion people lack access to clean water and each year 2. 5 million people die from contaminated water, 90% are under 5 years old. The World Health Organization has declared a worldwide water crisis among the worlds poorest people. Society has conditioned us to be overwhelmed with statistics and the quantity of need in the world. The easy thought process is to say theres too much and Im only one person. By taking one step at a time, one day at a time, one person at a time, theyre breaking down numbers and they believe in the power of one. 9 No One Without has aligned themselves with the Thirst Relief mission: To overcome death and disease resulting from the consumption of contaminated water by providing safe, clean water to those in need around the world. 2. 3. 1 Why Water? The solution to the clean drinking water need is found in the concrete Bio-sand filter. The Biosand filter has the ability to produce safe, clean drinking water from both contaminated surface water, and ground water sources. As a result, the simple yet affective technology provides a long-term, sustainable and economical drinking water solution to those in poverty stricken areas around the world. Thirst Relief International currently has Bio-sand filter placements in Brazil, Cameroon, Kenya, Rwanda, Tanzania, and Uganda. No One Without will follow Thirst Relief International around the globe on the quest for clean water. 10 2. 4 TOMS In 2006, American traveller Blake Mycoskie befriended children in a village in Argentina and found they had no shoes to protect their feet. Wanting to help, he created TOMS, a company that would match every pair of shoes purchased with a pair of new shoes given to a child in need. One for One. Realizing this movement could serve other basic needs, TOMS Eyewear was launched. With every pair purchased, TOMS will help give sight to a person in need. One for One. Over the past seven years, theyve listened and learned with every pair of new shoes given. With the support of their amazing network of Giving Partners and the continued support of their community, theyve reached this major milestone and proven that business can fuel good and sustain giving. They have seen remarkable results with shoe giving. Shoes are helping improve school attendance and enrolment. Theyre combined with screenings to combat malnutrition. Theyre given in conjunction with medication to fight hookworm. Further, their model is one that can work beyond shoes. Since they launched TOMS Eyewear, theyve helped restore sight to more than 150,000 individuals around the world. And they look forward to finding new ways to help others. They currently make Giving Pairs in Ethiopia, Kenya, Argentina and China. Within two years, they will produce one third of their Giving Shoes in the regions where they give them. By producing more shoes locally they will create and support jobs in places where they are needed. They are testing production in India and are looking to expand manufacturing in Africa and other regions. In Haiti, they are in the early stages of getting production off the ground. Theyve also partnered with local artists to create a line of hand-painted shoes for their customers helping create and support jobs in a place where they also give. And theyre looking to offer more styles that feature locally produced textiles. Their sight giving empowers communities and supports sustainable eye-care organizations in the developing world. They work with locally based organizations that train residents to provide professional care. So its an investment in clinics, people and even local jobs. 11 2. 5 Common Threadz Common Threadz is a non-profit organization helping orphans vulnerable children in developing nations to reach their full potential through the empowerment of the children, their caretakers the local grass roots community organizations that support them. 2. 5. 1 School Uniforms for Orphans Vulnerable Children This was the first initiative that Common Threadz created in 2008. For every t-shirt or bracelet that they sell from their Shop to Help Store, they give a school uniform to an orphan or vulnerable child (OVC) so they can go to, or stay in school. Some of the children they care for had been refused schooling for not being able to afford a uniform. Uniforms are a requirement in most schools in Africa and they want to make sure that all these children have the chance to go to school, make friends and learn so that they can reach their full potential. Since the inception of this program, hundreds of uniforms have been handed over to OVC’s. Typically a uniform will last a year and so there is an ongoing need for uniforms. As the caregivers they continuously work to identify the OVC’s in need and as support for this program grows, they plan to hand over many more uniforms in the future. 2. 5. 2 Orphan and Vulnerable Children (OVC) Mentor Program They currently operate a mentor program in Obanjeni, South Africa. This program teams responsible and employed adults from the local community with orphans and vulnerable children (OVC’s) as role models on a one-to-one basis. Each of their mentors supports many children, meeting with each child for at least one hour per week. The mentors spend time helping with homework, chatting about personal hygiene, advising on healthy lifestyles and most of all, listening to the child. In some cases these mentors have come back to them to report abuse and a child has had to be moved to a place of safety and the police and social workers are called in. The mentors are their ears and eyes in the community. The program has rolled out with many young children and teenagers benefiting greatly. Still in its infancy, this program has been a great success and will be replicated and expanded moving forward. 2. 5. 3 The Feeding Program Common Threadz provides the funding and nutritional guidance for grassroots non-profit organizations in rural South Africa, such as Siyathuthuka Obanjeni, to provide daily meals to over 200 orphans and vulnerable children (OVC’s) that they have identified in the area. Proper nutrition is a fundamental need for the children to grow and learn and although the government says that it’s a child’s right not to go hungry, this is far from the reality for many thousands of children in South Africa. This program has grown from its inception last year when caregivers began to cook three meals a week for children after school. Now an employed cook prepares a cooked meal every day for the children to eat after school and in April 2010 they started to provide high protein porridge for the children to eat on their way to school, as the teachers have indicated that it is very difficult for the children to concentrate when they are hungry. 12 Once again this program has much room to expand and reach many more needy OVC’s but it would not be possible without the support of their customers. 2. 5. 4 Shoes for Kids This program complements the School Uniforms Programme by providing new school shoes to barefoot children in need, namely orphans and vulnerable children (OVC’s). School uniforms might give these children entrance to school, however many of them walk for up to four hours a day to go to school barefoot. A new pair of school shoes is usually the only new pair of shoes most of these children will ever receive and for most of them it will be the only pair of shoes they will own. All it takes is $10 to provide an OVC with a new pair of shoes so that they can go to school with confidence. 2. 6 Threads for Thought What began as a small business manufacturing and marketing graphic tee shirts that were made exclusively from organic cotton, gave back to charity, and promoted a cleaner environment, or advocated for peace, has grown into a complete lifestyle brand. They have never deviated from their primary mission, to promote a sense of responsibility for those who share this world with us, but rather than simply broadcasting that message on the front of tee shirts, the company has incorporated those principles into their very existence. 2. 6. 1 How their threads are sustainable Threads 4 Thought fabrics are made using the most sustainable materials possible such as organically grown cotton and polyester derived from recycled water bottles. Their fabrics are dyed using low impact dyes whenever possible often the water used in the dye process is purified and then reused rather than being discarded. 13 2. 6. 2 Organic Cotton vs. Conventional Cotton ? ? ? ? ? ? ? Organic cotton is 90% less toxic than conventional cotton. Conventional cotton crops use more than 25% of all the insecticides in the world and 12% of all the pesticides while growing on only 2. 5 % of cultivated lands in the world. Organic cotton uses untreated seeds that are never genetically modified while conventional cotton uses genetically modified seeds, hurting the crops soil over time. Organic Cotton plants stay strong through crop rotation and retain water efficiently due to increased organic matter in the soil. Conventional cotton plants use synthetic fertilizers. Organic Cotton fields use seasonal freezes and water management for defoliation. Conventional cotton does this through the use of toxic chemicals. Weeds are physically removed by hand hoeing and cultivation. Farmers use beneficial insects and trap crops to control pests. Conventional cotton uses a toxic aerial spraying technique. 2. 6. 3 Turning Plastic into fashion 1. The plastics are sorted according to colour and SNV plastics. 2. Next, the plastic goes through a sterilization process. Then, it is dried and crushed into chips. Next, liquefaction occurs under high temperatures, as a mixture of the recycled chips and some new plastic from petroleum derivatives are melted together to form a smooth, syrup-like material. 3. The first threads are formed when the liquefied material is forced through holes and exposed to air. The hardened threads, called tow, then go through a strengthening process. 4. The drawing process strengthens the molecular bonds of the tow; the tow is pulled to double their size and then shrunken. 5. The threads then go through a dryer where they develop a woolly texture. The texture is inspected for strength and thickness, and then spun into a finer yarn that is then ready to be dyed and knit into fabric. 14 2. 7 147 Million Orphans Profits from 147 Million Orphans are directed to the 147 Million Orphans Foundation, where they are given to Love+ 1 Projects and feeding programs. The 147 Million Orphans Foundation was created to impact the lives of children through the provision of food, water, and medicine. They invest directly in projects that help provide these basic needs to those who desperately need it, and most of their projects occur in Haiti, Honduras, and Uganda. As with any good foundation you must lay one brick at a time. Whether that is a medical clinic in Haiti, homes in Honduras, Water Wells in Sudan, or a store house full of food for Uganda, they want to show the love of Christ. The rebuilding of the wall in Nehemiah was accomplished by people just doing their part and helping others to do theirs. The Love+ 1 projects are steps in rebuilding, and they would love for us to be a part of the rebuilding. 2. 7. 1 During 2012 and 2013, the Love+ 1 Projects Included: ? ? ? ? ? ? ? ? ? ? ? ? ? ? Provided funding for over 100,000 meals for children in Uganda, Haiti, and Honduras Helped to build clean water wells in Sudan and Honduras Provided funding for HIV education and medicine in Uganda and Haiti Provided funding for a vehicle, appliances and kitchen construction for an orphanage in Haiti Funded the construction costs of 27 homes in Mt. Olivos, Honduras for displaced families. These 2 bedroom, concrete homes with running water are allowing families to remain intact and raise their children in a healthy environment. They are building a strong community, including a school and a weekly worship service. Provided over 150 cans of formula to an infant feeding nutrition program in Haiti Raised $200,000 of the $250,000 needed for construction of the Love+ 1 Medical Centre in Gressier, Haiti where there are currently no medical or dental facilities available to the 35,000 residents. This centre will include a doctor’s office with a pharmacy, a dental office, an urgent care clinic, and an operating room. This clinic will be located on land adjoining a school that currently serves over 400 children. Raising the final $50,000 and beginning construction of the Love+ 1 Medical Centre in Haiti – a 5,000 square foot facility with medical and dental facilities for a community of 35,000 people with no medical care. The medical facility is expected to open in October 2013 with ongoing funding needs for supplies and equipment. Construction of a tilapia pond for the community of Mt. Olivos, Honduras. Completion of the construction of all homes in Mt. Olivos, Honduras. Formula for an infant feeding and nutrition program in Haiti Food and medicine to children in Uganda, Haiti, and Honduras Bedding and supply needs for an orphanage in Uganda Food to children in Tennessee through a weekly backpack program 15 2. 8 I Am A Star I AM A STAR is built on a solid foundation of trust and collaboration. It is rooted in the Somali diaspora communities leadership, and it makes room for the solidarity and creativity of motivated people everywhere. Together, theyre providing relief in Somalia, and shining a light on a culture of poets, artists, mothers and fathers, children, innovators, farmers, businesspeople. Each one, a star in his or her own right. Perched on the very tip of the Horn of Africa, Somalia has suffered two decades of hardship, violence and displacement. Its estimated that 25% of the countrys population have fled their homes, traveling to Kenya and Ethiopia or to other parts of Somalia. Since the summer of 2011, the country has faced a crippling food crisis. Between 50,000 to 100,000 Somalis have died as a result. US Secretary of State, Hillary Rodham Clinton called it the most severe humanitarian emergency in the world today-and the worst East Africa has seen in decades. Thanks to the spirit and efforts of the worldwide Somali Diaspora and other compassionate individuals, organizations and governments, relief is getting to people who need it. Donors have looked past the negative imagery of Somalia in the media and sent their support. That support has saved the lives of mothers and fathers, children, poets, artists, innovators, farmers, businesspeople, human beings. But there is still so much that needs to be done in Somalia. The famine has ended, but 1 in 5 Somali children are still malnourished. 2. 5 million people are still dependent on food aid in order to survive. It will take an investment of time and great effort to shake off the legacy of 20 years of war and unrest in Somalia. The country has the worlds lowest rates of school enrolment, and experts estimate that 18% of children born in Somalia will not live to age 5. 2. 8. 1 With Support from: ? ? ? ? ? ? ? ? ? ? KNAAN 4Real IDEO Pivotal Labs Heroku Music for Relief Mataano Chef Roble Co. Faarrow Mosaic 16 2. 9 Soles 4 Souls Soles4Souls is a global not-for-profit institution dedicated to fighting the devastating impact and perpetuation of poverty. The organization advances its anti-poverty mission by collecting new and used shoes and clothes from individuals, schools, faith-based institutions, civic organizations and corporate partners, then distributing those shoes and clothes both via direct donations to people in need and by provisioning qualified micro-enterprise programs designed to create jobs in poor and disadvantaged communities. Based in Nashville, Tennessee, Soles4Souls is committed to the highest standards of operating and governance, and holds a four-star rating with Charity Navigator. Founded in 2004, Soles4Souls is a global not-for-profit institution dedicated to fighting the devastating impact and perpetuation of poverty through the distribution of shoes and clothing. Soles4Souls distributes shoes and clothing in two ways. Most new items collected primarily from corporations and retailers are given directly to people in need, both in the U. S. and overseas. The organization has relationships with several of the world’s leading apparel brands, which provides Soles4Souls with new but non-marketable overstocks, returns, discontinued models and other shoes or clothing items. At the same time, Soles4Souls receives millions of articles of used shoes and clothing that have been collected by individuals, schools, faith-based institutions, civic organizations and corporate partners. After sorting items in its national warehouse system, Soles4Souls typically sells the used shoes and clothing, as well as some new items allocated by manufacturers, to carefully selected micro-enterprise organizations. These both private and non-profit companies are contracted to provide shipping, financing, inventory, training and other support to ultrasmall businesses in countries like Haiti where there are virtually no jobs to generate personal income. Through the collection and sale of used (and new) clothing and shoes, Soles4Souls helps create self-sustaining jobs that generate desperately needed revenues throughout those communities. The sale of footwear and apparel to support micro-jobs also provides the majority of funding to sustain Soles4Souls operations and further expand its donations of new shoes and clothing. 17 2. 10 FEED FEED Projects mission is to create good products that help FEED the world. They do this through the sale of FEED bags, be

Julius Caesar and John Locke’s Treatise of government

Julius Caesar and John Locke’s Treatise of government Julius Caesar and John Locke’s Treatise of government. Explain the John Locke’s conspiracys reasons for taking action. In conversing Lockes Two Treatises of Government, Locke sets out his own perspective and arguments the complete power of the king to function without the agreement of the people. The main purpose of Locke’s second treatise is to sketch the suitable form for a society and government and to elucidate why his plan was suitable. Locke speaks that the only purpose for having a control is to protect the usual rights that people must enjoy simply due to the fact that they are mortal. However, when a rà ©gime or king (in this situation of Charles II), fails its individuals, the people are constrained to upheaval and start the rightful king (William, the Great Restorer). Thus, Locke inscribed his second treatise, in part, to show his backing for William III as king. (Locke and Laslett) Explain any relevant concepts discussed by Locke (civil government dissolution of government) Locke asserts that genuine administration is based on the notion of separation of powers. Main and leading of these is the legislative influence. Locke defines the governmental power as best (Two Treatises2.149) in consuming final power over â€Å"how the power for the state shall be engaged† (2.143). The government is still destined by the rule of natural surroundings and much of what it does is set down rules that additionally the objectives of normal law and identify appropriate sentences for them (2.135). The decision-making power is then indicted with enforcing the law as it is practical in explicit cases. Captivatingly, Locke’s third power is named the â€Å"federative power† and it contains the right to act globally conferring to the law of nature. If we relate Locke’s preparation of parting of influences to the advanced ideas of Montesquieu, we understand that they are not as diverse as they may originally seem. Locke’s federative control and the legal power as apprehensive with the local execution of the laws Locke’s policymaking power, it is more than a terminology than the thoughts that have altered. Locke deliberated arresting a person, trying an individual, and penalizing a individual as all part of the purpose of executing the rule rather than as a separate function. The concept of an â€Å"appeal to heaven† is a significant idea in Locke’s believes. Locke accepts that people, when they leave the public of nature, make a government with some sort of constituents that stipulates which bodies are allowed to exercise which commands. Locke also undertakes that these authorities will be used to defend the rights of the individuals and to endorse the community good. In cases where there is a argument between the individuals and the government about whether the government is satisfying its duties, there is no advanced social authority to which one can appeal. The only plea left, for Locke, is the plea to God. The â€Å"appeal to heaven,† consequently, involves taking up arms against your opponent and letting God judge who is in the right. A clear position on how Locke would assess the conspiracy according to those concepts Lockes theory of confrontation does not rest on on the legal fiction, of direct majority rule; actually the philosophy of resistance originates from the right of civilization to society a government which is sanctioned by the assent of the majority, which places genuine responsibilities on all members of society, and which functions for community good. The utmost danger to harmony and accord in culture — primary to its disaggregation — is an unlawful modification of its lawmaking that leaves no familiar authority. Confrontation to unlawful administration act is meant to anticipate this possibility. Where this confrontation is too little or too late we need to regulate the conditions in which it is still defensible, despite a lack of former vigilance, though we must suppose that late and incomplete action may demonstrate to be ineffective. It is the failure of government that defends resistance and, henceforth, legitimate confrontation is reliant on upon an precise, judicious and just valuation of governments activities. Evaluation of the decision how Locke would kill Caesar and how he would judge the actions of such characters as Caesar, Brutus, Cassius, and Mark Antony. (Direct textual analysis of both works.) In Shakespeare’sJulius Caesar, Brutus’s killing of Julius Caesar is an ethically vague event. Therefore, we under no circumstances truly know whether we must back Brutus or Caesar because, while Brutus is labelled as a decent man who is performing in the welfares of the average Roman, Caesar enjoys traits that Shakespeare has made able to be understood as strong and good or as tyrannical. In the play, (Shakespeare) Brutus is exemplified as the honorable Roman with Marc Antony, his opponent, shouting him â€Å"the noblest Roman of them all.†(5.5.69) since of this point, if Brutus had been the one to propose the murder of Caesar, the murder could be deliberated an ethical, essential act. But it was Cassius, not Brutus, who originated up with the idea. Cassius’s cautious operation of Brutus is the basis of the act, meaning that, from the start, the idea was unreliable. Even when Brutus states â€Å"Let us be sacrifices, but not butchers†(2.1.167), which must be understood as him trying to take a additional moral path, he moreover embraces â€Å"Let’s carve him as a dish fit for the gods†(2.1.174), which exemplifies the fact that, good intents or not, the collaborators are still arguing murder, and mutilation at that. While Shakespeare is able to demonstrate murder, the worst likely action, as probably the ethical path, what regulates th e spectator’s opinion of the entire play is one query: In the public, can assassination ever be reflected the ethically right option? The response, according to the theorists Locke, Rousseau, Kant, and many others is no, it cannot ever be measured ethical. These thinkers’ views can preeminently be shortened by a quote from Locke’sSecond Treatise on Government, that â€Å"all mankind being all equivalent and sovereign, no one ought to harm another in his life, health, liberty or belongings†, which comprises that murder is thought to be measured completely incorrect. While this quote, one of the establishing principles of our own state, is totally against assassination, I believe that, in our flawed world, it is tough to say an act is individually incorrect and that there doesn’t be even one situation that homicide could be measured the finest option. Though the quote is individually against killing, it also includes â€Å"liberty† as somewhat that â€Å"ought not to be damage[ed]†, which, as oppressors typically infringe upon rights, brings up the query: When two of these mo rals oppose, what should do we do? I believe while Brutus and the plotters have good intents that could cause the killing to be tolerated, they do not, in my observance, have the essential circumstances. The plotters’ belief that Caesar will become a oppressor, and that preventive action is necessary to protect Rome, is founded upon many expectations. And in this case, when homicide is the preventive action, I think expectations, right or wrong, aren’t sufficient to defend a killing, but undisputable proof of Caesar’s oppression is essential. While I do not wholly agree with the absolutist declaration of Locke and Rousseau that killing is individually depraved and is not ever the best choice, I do trust that the individual or people anticipating killing a single need to have the best of purposes and undisputable evidence to support the motive for the decision. While murder can never be measured a good action, it will continuously be spoiled for good motives, it can be measured the best way of act in that it may be used to defuse proven oppressors and other persons that, if gone in our world, may cause the deaths and grief of many more person. In the case ofJulius Caesar, the conspirators’ movements cannot be reflected ethical or defensible because they required undisputable proof that Caesar was an oppressor and consequently required the necessary state in which murder could be accepted as a essential action. Bibliography: Locke, John, and Peter Laslett. Two Treatises of Government. Cambridge [England]: Cambridge University Press, 1988. Print. Shakespeare, William, and Arthur L. Humphreys.The Oxford Shakespeare. ; Julius Caesar.Oxford UP, 2008. Print. Shakespeare, William. The Tragedy Of Julius Caesar. Champaign, Ill.: Project Gutenberg. Print.

High Performance Liquid Chromatography Experiment

High Performance Liquid Chromatography Experiment INTRODUCTION Pharmaceutical Analysis may be defined as the application of analytical procedures used to determine the purity, safety and quality of drugs and chemicals. The term Pharmaceutical analysis is otherwise called quantitative pharmaceutical chemistry. Pharmaceutical analysis includes both qualitative and quantitative analysis of drugs and pharmaceutical substances starts from bulk drugs to the finished dosage forms. In the modern practice of medicine, the analytical methods are used in the analysis of chemical constituents found in human body whose altered concentrations during disease states serve as diagnostic aids and also used to analyze the medical agents and their metabolites found in biological system. Qualitative inorganic analysis seeks to establish the presence of given element or inorganic compound in a sample. Qualitative organic analysis seeks to establish the presence of a given functional group or organic compound in a sample. Quantitative Quantitative analysis seeks to establish the amount of a given element or compound in a sample. The term quality as applied to a drug product has been defined as the sum of all factors, which contribute directly or indirectly to the safety, effectiveness and reliability of the product. These properties are built into drug products through research and during process by procedures collectively referred to as Quality control. Quality control guarantees with in reasonable limits that a drug products Is free of impurities. Is physically and chemically stable Contains the amount of active ingredients as stated on the label and Provides optimal release of active ingredients when the product is administered. Most modern analytical chemistry is categorized by two different approaches such as analytical targets or analytical methods. INTRODUCTION FOR CHROMATOGRAPHY: High performance liquid chromatography is the process, which seperates mixture containing two or more components under high pressure. In this the stationary phase is packed in column one end of which is attached to a source of pressurized liquid mobile phase. High performance liquid chromatography is the fasted growing analytical technique for the analysis of drug. Its simplicity, high specificity and wide range of sensitivity makes its ideal for the analysis of many drugs in both dosage form and biologic fluids. HPLC is also known as High performance liquid chromatography. It is essential form column chromatography in which the stationary phase is consists of a small particles (3-5o µm) packing contained in a column with a small bore (2-5mm), one end of which is attached to source of pressurized liquid eluent(mobile phase). Different Types of Principles: According to the phases involved, HPLC can be classified into several types, which are as follows: Normal Phase Chromatography (NPC) Reverse Phase Chromatography (RPC) Liquid Solid Chromatography or adsorption HPLC Liquid Liquid Chromatography or Partition HPLC Ion exchange Chromatography or Ion exchange HPLC Size exclusion or gel permeation or steric exclusion HPLC 1. Normal Phase Chromatography (NPC): In normal phase chromatography, the stationary phase is more polar then the mobile phase, and the mobile phase is a mixture of organic solvents with out added water (e.g. isopropane with hexane) and the column packing is either an inorganic adsorbent (silica) are a polar bonded phase (cyanno, diol, amino) on a silica support. Sample retention in normal phase chromatography increases with the polarity of mobile phase decreases. They are eluted in the order of increasing polarities. 2. Reverse Phase Chromatography (RPC): In reverse-phase chromatography, the stationary phase is less polar than the mobile phase and the mobile phase is a mixture of organic and aqueous phase. Reverse-phase chromatography is typically more convenient and rugged than the other forms of liquid chromatography and is more likely to result in a satisfactory final separation. High performance RPC columns are efficient, stable and reproducible. In this, the solutes are eluted in the order of their decreasing polarities. These are prepared by treating the surface silanol group of site with an organic chloro silane reagent. INSTRUMENTATION: RECORDER SCHEMATIC DIAGRAM OF HPLC a. Pumps: Pumps are required to deliver a constant flow of mobile phase at pressures ranging from 1 550 bar pumps capable of pressure up to 6000 psi provide a wide range of flow rates of mobile phase, typically from 0.01-10ml min-1. Low flow rates (10-100à ¯Ã‚ Ã‚ ­l min-1) are used with micro bore columns, intermediate flow rates (0.5-2ml min-1) are used with conventional analytical HPLC columns, and fast flow rates are used for preparative or semi preparative columns and for slurry packing techniques. Mechanical pumps of the reciprocating piston type view a pulsating supply of mobile phase. A damping device is there fore required to smooth out the pulses so that excessive noise at high levels of sensitivity or low pressure does not detract from detection of small quantities of sample. This type of pump is mostly used. Dual piston reciprocating pumps produce an almost pulse free flow because the two pistons are carefully faced so that as one is filling the other is pumping. These pumps are more expensive than single piston pumps but are of benefit when using a flow sensitive detector such as ultraviolet or refractive index detector. b. Injection Systems: Injection ports are of two basic types, (A) those in which the sample with injected directly into the column and (B) those in which the sample is deposited before the column inlet and then swept by a valving action into the column by the mobile phase. c. Columns: HPLC columns are made of high quality stainless steel, polish internally to a mirror finish. Standard analytical columns are 4-5 mm internal diameter and 10-30 cm in length. Shorted columns (3-6 cm) containing a smaller particles size packing material (3 or 5 à ¯Ã‚ Ã‚ ­m) produce similar or better efficiencies, in terms of the number of theoretical plates (about 7000), that those of 20 cm columns containing 10 à ¯Ã‚ Ã‚ ­m irregular particles and are used an short analysis time and highest throughput of samples are required. Micro bore columns of 1-2 mm internal diameter and 10-25 cm in length have certain advantages of lower detection limits and lower consumption of solvent, the latter being important if expensive HPLC grade solvents are used. HPLC are also being carried out on the semi preparative scales by using columns of 7-10 mm or 20-40 mm internal diameter respectively. d. Detectors: The most widely used detectors for liquid chromatography are Detector Analytes Solvent Requirements Comments UV-Visible Any with chromophores UV-grade non UV absorbing solvents Has degree of selectivity and useful for many HPLC applications Fluorescence Fluorescent compounds UV-grade non UV absorbing solvents Highly selective and sensitive, often used to analyze derivitized compounds Refractive index Compounds with different RI than mobile phase Cannot run mobile phase gradients Limited sensitivity Conductivity Charged or polar compounds Mobile phase must be conducting Excellent for ion exchange compounds Electrochemical Readily oxidized or reduced compounds, specially biological samples Mobile phase must be conducting Very selective and sensitive Mass-Spectrometer Broad range compounds Must use volatile solvents or volatile buffers Highly sensitive. Many modes available. Needs trained person Theoretical principles of HPLC: a. Retention time: The time is required between the injection point and the peak maximum is called the retention time. It is denoted as the Rt. It is mainly useful for the qualitative analysis for the identification of compound. b. Capacity factor: It represents the molar ratio of the compound in the stationary phase and the mobile phase. It is independent of column length and mobile phase flow rate. It is denoted as the k. It should be kept 1-10. If k values are too low it is likely that the solutes may be adequately resolved and for high k values the analysis time is too long. It can be calculated by tr t0 k = - t0 tr = Retention time, t0 = Dead time. c. Tailing factor: Closer study of a chromatographic show that the Gaussian forms is usually not completely symmetrical. The graph spread out to a greater or lesser extent, forming a tail. It reduces the column plate number which intern influences the resolution. Tailing is mainly due to deteriorated column, overloading column, extra column-volumes, and incompatibility of sample with standard and/or mobile phase. Practically it can be calculated or determined at 10% of the total peak height. It must not be greater than 2.0 d. Resolution: The degree of separation of one component from another is described by the resolution. It is generally denoted by Rs. It is measured as the difference in retention time and the arithmetic mean of the two peak widths. tr2 tr1 Rs = 0.5(w1 + w2) tr2 = Retention time of first peak w1 = width of first peak tr1 = Retention time of second peak w2 = width of second peak e. Theoretical plates: It is important property of the column. It reflects its quality of separation and its ability to produce sharp, narrow peak and achieving good resolution of peak. N denotes it. 3500 X L (cm) Theoretical plates = - dp( µm) L = length of the column in cm, dp = diameter of the particle ( µm) It follows that if the exchange is fast and efficient, the theoretical plate will be small in size and there will be large number of plates in the column. f. Height equivalent to theoretical plate (HETP): Number of plates directly proportional to the column length (L) and inversely proportional to the diameter of the particles (dp). The value of H is a criterion for the quality of a column. Lower the HETP, higher is the efficiency of the column. Its value depends upon particle size, flow rate, viscosity of mobile phase. H = L/N L = Length of column, N = No. of theoretical plate HPLC method development: The wide variety of equipment, columns, eluent and operational parameters involved makes high performance liquid chromatography (HPLC) method development seem complex. The main objective of method development is to obtain a good separation with minimum time and effort. Based on the goal of separation, the method development is preceded. The steps involved are: Information on sample, define separation goals Need for special HPLC procedure, sample pretreatment, etc. Choose detector and detector settings Choose LC method, preliminary run; Estimate best separation conditions Optimize separation conditions Check for problems or requirement for special procedure Validation for release to routine laboratory The following must be considered when developing an HPLC method: Keep it simple Try the most common columns and stationary phases first Thoroughly investigate binary mobile phases before going on to ternary Think of the factors that are likely to be significant in achieving the desired resolution. Mobile phase composition, for example, is the most powerful way of optimizing selectivity whereas temperature has a minor effect and would only achieve small selectivity changes. pH will only significantly affect the retention of weak acids and bases. VALIDATION OF ANALYTICAL METHOD IN PHARMACEUTICAL ANALYSIS: Validation is documented evidence, which is completed to ensure that an analytical method is accurate, reproducible and robust over the specific range. The quality of the analytical data is a key factor in the success of a drug development program. The process of method development and validation has a direct impact on the quality of these data. Method validation: Method validation is the process to confirm that analytical procedure employed for a specific test is suitable for its intended use. Method needs to be validated or revalidated Before their introduction into routine use Whenever the conditions changes for which the method has been validated , e.g., instrument with different characteristics Whenever the method is changed, and the change is outside the original scope of the method. Depending on the use of the assay, different parameters will have to be measured during the assay validation. ICH and several regulatory bodies and Pharmacopoeia have published information on the validation of analytical procedures METHOD VALIDATION PARAMETERS: SPECIFICITY. ACCURACY. PRECISION. LINEARITY. ROBUSTNESS. SOLUTION STABILITY. The goal of the validation process is to challenge the method and determine the limit of allowed variability for the conditions needed to run the method. The following statistical parameters are to be determined to validate the developed method. Correlation coefficient(r): When the changes in one variable are associated or followed by changes in the other, it is called correlation. The numerical measure of correlation is called the coefficient of correlation and is defined by the relation. à ¯Ã‚ Ã¢â‚¬Å" (x x) (y -y) r = à ¢Ã‹â€ Ã… ¡ à ¯Ã‚ Ã¢â‚¬Å"(x -x) 2 à ¯Ã‚ Ã¢â‚¬Å"(y -y Regression equation: Regression equation= I + aC Y2 Y1 a = slope = X2 X1 I = Intercept = regression a C As a percentage of mean absorbance. 3. Standard Deviation: S = à ¢Ã‹â€ Ã… ¡ à ¯Ã‚ Ã¢â‚¬Å" (X- X!) 2/N 1 Where, X = observed values X! = Arithmetic mean = à ¯Ã‚ Ã¢â‚¬Å"X/N N = Number of deviations For practical interpretation it is more convenient to express S in terms of percent of the approximate average of the range of analysis is used in the calculation of S. This is called co-efficient of variation (C.V) or percent relative standard deviation (%RSD). C.V OR %RSD = 100* S/ X! Criteria for Validation of the Method CHARACTERISTICS ACCEPTABLE RANGE Specificity No Interference Accuracy Recovery (98-102%) Precision RSD Linearity Correlation Coefficient(r)>0.99 Range 80-120% Stability >24h or >12h DRUG PROFILE RIZATRIPTAN BENZOATE: Structure: Chemical name : N,N diethyl -5-(1H-1,2,4-triazol-1-1-ylmetyl)-1H Indole-3 Ethanamine monobenzoate Molecular Formula : C15H19N5.C6H5COOH Molecular weight : 391.47 Description: White crystalline powder Melting point: 178-1800C Solubility: Sparingly soluble in water and methanol Storage: Air tight container protect from light. Drug Category: Anti migraine drug THERAPEUTIC RATIONAL RIZATRIPTAN BENZOATE: CLINICAL PHARMACOLOGY: Mechanism of action: Rizatriptan binds with high affinity to human 5-HTIB and 5-HTID receptors leading to cranial blood vessel constriction. Pharmacokinetics: Absorption: Completely absorbed from GI tract, absolute bioavailability is 45% plasma peak concentration attained with in 1-1.5 hours (conventional tablet )or 1.6-2.5 hours (orally disintegrating tablet)after oral administration. Distribution: Crosses placenta and is distributed in to milk in animal, no studies in pregnant or nursing women. Metabolism: Metabolized principally via oxidative deamination by Mao-A to an inactive indole acetic acid metabolite Elimination: Excreted principally in urine(14% of dose as unchanged drug and 51 % a indole acetic acid metabolite Adverse effects: Dry mouth Dizziness Pain tightness/pressure in neck/throat/jaw. Nausea Chest pain Parasthesia Fatigue Dosage and administration: The dose range of Rizatriptan benzoate is 10-30mg orally once daily.Rizatriptan benzoate can be administer orally disintegrating tablet with out meals. LITERATURE REVIEW Sasmitha Kumar et al: has been developed UV spectroscopic method for estimation of Rizatriptan benzoate.The drug shows maximum absorption at 277 nm and 281 nm and obeys beer-lamberts law in the concentration of 0.5-20  µg/ml at 277 nm and 0.5-80  µg/ml at 281 nm respectively. The percentage recovery was found to be 97-100%. Madhukar et al; has been developed reverse phase high performance liquid chromatographic method for determination of Rizatriptan benzoate. The proposed method utilized column L1 inertsil ODS-3v, 250 nmx4.6 mm having particle size, 5 µm. The mobile phases were comprised of A, B of Acetonitrile and buffer pH 6.5 at UV detection 225 nm.The method shows recovery 96.64-97.71 Sachin jagthap et al; has been developed stability indicating reversed phase high performance liquid chromatographic method for the determination of Rizatriptan benzoate in bulk powder and in pharmaceutical formulations. The method utilizes c18 column having dimension 250mmx4.6 mm having particle size,5.0  µm using a mobile phase 0.01M sodium dihydrogen phosphate buffer: Methanol , at a flow rate 1ml/min at ambient temperature and detected at 225 nm.and the method was validated according to ICH guidelines Quizi zhang et al: has been developed, a high performance liquid chromatographic method for the determination of Rizatriptan benzoate in human plasma.using asingle step liqid liqid extraction with metyl tertiary butyl ether, the analytes separated usig amobile phase consisting of 0.05%v/v triehylamine in water adjusting ph 2.75 with 85% phosphoric acid and acetonitrile.fluroscence detection was performed at an excitation wavelength of 225 nm and an emission wavelength of 360 nm.The linearity for rizatriptan was within the concentration range of 0.5-50ng/ml. Rajendra Kumar et al: has been developed and validated stability a stability indicating high performance liquid chromatographic method for Rizatriptan benzoate.The force degradation studies were performed on bulk sample of Rizatriptan benzoate. The method utilizes a zorbax SB-CN column with dimension of 250 mmx4.6 mm, 5um column. The mobile phase consists of a mixture of aqueous potassium dihydrogen ortho phosphate (ph3.4), acetonitrile and methanol. Rauza bagh et al: has been developed a spectroscopic method for analysis of Rizatriptan benzoate in bulk and tablet dosage form. The Rizatriptan benzoate shows maximum absorbance at 225 nm. Beers law was obeyed in the concentration range of 1-10 µg/ml. AIM AND PLAN OF WORK The present aim is to develop a new simple and rapid analytical method to estimate the Rizatriptan benzoate The plan of the proposed work includes the following steps: To undertake solubility studies for analytical studies of Rosuvastatin calcium Develop initial chromatographic conditions. Setting up of initial chromatographic conditions for the assay of Rosuvastatin calcium Optimization of initial chromatographic conditions. Validation of the developed HPLC Analytical method according to ICH method validation parameters. EXPERIMENTAL NEW RP-HPLC METHOD FOR THE ESTIMATION OF RIZATRIPTAN BENZOATE IN TABLET DOSAGE FORM A simple reverse phase HPLC methods was developed for the determination of Rizatriptan benzoate in tablet dosage form. Zorbax Eclipse XBD C18 (250 cm ÃÆ'- 4.6 mm) column in isocratic mode with mobile phase Buffer ph 5.0: Methanol (80:20) was used and pH-3 adjusted with tri ethylamine. The flow rate was 1.0 ml/min and UV detection at 225nm. The retention time 3.0 min. The proposed method was also validated. EXPERIMENTAL 1. Instrumentation: Shimadzu LC-10A HPLC Vacuum pump Gelmon science Elico SL-164 double beam UV-Visible spectrophotometer Ultra sonicator 3.5L 100(pci) 2. Chemicals: Water HPLC grade Methanol HPLC grade (Merck) Potassium dihydrogen orthophosphate(AR Grade) Triethylamine (AR Grade) 5.1 OPTIMIZATION: 1. Selection of wavelength: After solubility study for the drug solvent was selected and appropriate concentration of Rizatriptan benzoate standards with solvent were prepared. The solution were then scanned by using doubl beam UV-Visible spectrophotometer the range between 200-400nm.The overlain spectra for the both drug were observed and maximum wavelength was finally selected. 2. Selection of mobile phase: To develop a prà ©cised and robust HPLC method for determination of Rizatriptan benzoate , its standard solution were injected in the HPLC system. After literature survey and solubility data different composition of mobile phase of different flow rates were employed in order to determine the best condition for effective separation of drugs. 3. Selection of column: Initially different C8 and C18 columns were tried for selected composition of mobile phase and quality of peaks were observed for the drugs. Finally the column was fixed upon the satisfactory results of various system suitability parameters such as column efficiency, retention time, tailing factor / peak asymmetry of the peaks. Other parameters such as flow rate, column temperature etc. were selected by varying its value up to certain levels and results were observed. The value at satisfactory results were obtained has been selected for the method. The final selection of chromatographic conditions as follows Optimized chromatographic conditions Preparation of Buffer ph 5.0: Dissove 2.76 gm of potassium dihydrogen orthophosphate in 1000ml of HPLC water plus 5.0 mlof Triethylamine. Mix and adjust PH 5.0 with orthophosporic acid. Filter with 0.45u nylon filter. Preparation of mobile phase: The mobile phase was prepared by mixing Buffer: Methanol (80:20). the solution was then filtered through 0.45ÃŽÂ ¼m membrane filter and sonicated. Preparation of standard stock solution: Standard solution of the pure drug was prepared by dissolving 73.0 mg of Rizatriptan benzoate in 100ml volumetric flask. The drugs were dissolved by using mobile phase as a diluent. Add about 50ml of diluent and sonicate to dissolve. Make up the volume with diluent. Mix well. Further dilute 5.0ml of the above solution to 250ml with diluent, mix well. Preparation of sample solution: Weight and transfer 10 intact tablet in into a100ml volumetric flask. Add about 50ml of diluent and sonicate for 15 min and make up the volume with diluent. Mix well, filter through 25 mm 0.45 u nylon , discard 4ml filtrate. Further dilute 5ml of the solution to 250 ml with diluent and mix well. CONCLUSION The evaluation of obtained values suggests that the proposed HPLC methods provide simple, precise, rapid and robust quantitative analytical method for determination of Rizatriptan benzoate in tablet dosage form. The mobile phase is simple to prepare and economical. After validating proposed method as per ICH guidelines and correlating obtained values with the standard values, satisfactory results were obtained. Hence, the method can be easily and conveniently adopted for routine estimation of Rizatriptan benzoate in tablet dosage form.